Levant Dirikolu

Levent Dirikolu

Professor of Pharmacology

Director, Equine Medication Surveillance Laboratory

Department of Comparative Biomedical Sciences

LSU School of Veterinary Medicine
Louisiana State University
Baton Rouge, LA 70803

EMAIL DR. DIRIKOLU

EQUINE MEDICATION SURVEILLANCE LAB

Education

PhD, University of Kentucky

MVSc, University of Kentucky

DVM, Ankara University (Turkey)

Research Interest

Pharmacokinetics, Pharmacodynamics, Molecular, Clinical and Analytical Pharmacology, Drug metabolism.

Teaching Interest

Clinical Pharmacology Rotations, Pharmacology (evidence based medicine and applied clinical pharmacology), Comparative Dispositions of Xenobiotic, Veterinary Pharmacology, Comparative Clinical Pharmacology, Advanced Clinical Pharmacology. 

Clinical Interest

Clinical Pharmacology Rotations

Awards & Honors

2021, Dean's Teacher Merit Honor Roll (2nd and 3rd years)

2020, Dean's Teacher Merit Honor Roll (2nd year)

2019, Dean's Teacher Merit Honor Roll (2nd and 3rd year)

2018, Dean's Teacher Merit Honor Roll (3rd year)

2017, Dean's Teacher Merit Honor Roll (3rd year)

2016, Phi Zeta poster presentation (Third place)

2015, Elected by the CVM Class of 2015 as a Hooder for Commencement

2015, Teacher Ranked as Excellent

2014, Elected by the CVM Class of 2014 as a Hooder for Commencement

2014, Elected by the CVM Class of 2015 as a Draper for White Coat Ceremony

2014, Teacher Ranked as Excellent

2013, Elected by the CVM Class of 2014 as a Draper for White Coat Ceremony

2012, Dr. Erwin Small Teaching Excellence Award

2012, Elected by the CVM Class of 2012 as a Hooder for Commencement

2012, Teacher Ranked as Excellent

2011, Dr. Erwin Small Teaching Excellence Award

2011, Pfizer Research Excellence Award

2011, Teacher Ranked as Excellent

2010, Elected by the CVM Class of 2011 and 2012 as a Draper for White Coat Ceremony

2010, Teacher Ranked as Excellent

2009, Teacher Ranked as Excellent 

2008, Arnold O. Beckman Research Award

2006, Pfizer Animal Health Research Excellence Award

2005, Norden Distinguished Teacher of the Year Award

2004, Faculty Performance Award

2003, Involved in the development of first FDA approved therapeutic medications for the treatment and prophylaxis of Equine Protozoal Myeloencephalitis based on the use of triazine drugs

1997, Honor student program 

Publications

Pharmacokinetic and safety profiles of three dose rates of morphine sulfate following single intravenous, intramuscular, and subcutaneous administration in the goat.  Gordon, E, Dirikolu L, Chi Liu CC, Li Z, PhD, Welborn M, Armstrong C, Vallotton D, Scully CM.  J Vet Pharmacol Ther. September 7, 2021.  doi: 10.1111/jvp.13011 https://pubmed.ncbi.nlm.nih.gov/34494277/ 
 
Dexamethasone serum concentrations after intravenous administration in horses during race training.  McClure S, Fenger C, Kersh K, Brown B, Maylin G, Duer W,  Dirikolu L, Brewer K, Machin J and Tobin T.  Comparative Exercise Physiology, December 2020, doi: 10.3920/CEP200015 
 
Liquid chromatography/tandem mass spectrometric analysis of penicillamine for its pharmacokinetic evaluation in dogs. Lehner AF, Dirikolu L, Johnson M, Buchweitz JP, Langlois DK.  Toxicol Mech Methods, 2020 Nov;30(9):687-702. doi: 10.1080/15376516.2020.1814467. https://pubmed.ncbi.nlm.nih.gov/32854553/ 
 
Ellerbrock RE, Canisso IF, Roady PJ, Rothrock LT, Zhong L, Wilkins P, Dirikolu L, Lima FS, Honoroto J. Diffusion of enrofloxacin to pregnancy fluids and effects on fetal cartilage after intravenous administration to late pregnant mares.  Equine Vet J. 2019 Jul;51(4):544-551. doi: 10.1111/evj.13044. https://pubmed.ncbi.nlm.nih.gov/30449030/ 
 
Dirikolu L, Waller P, Waguespack ML, Andrews FM, Keowen ML, Gaunt SD.The effect of sodium bicarbonate and validation of beckman coulter AU680 analyzers for measuring total carbon dioxide (TCO2) concentrations in horse serum.  Vet Med Sci. 2017 Oct 25;3(4):263-269. doi: 10.1002/vms3.82 (one of the journal’s top 20 most downloaded recent papers) https://pubmed.ncbi.nlm.nih.gov/29152319/ 
 
Rachel J. Tulipan RJ, Phillips H, Garrett LD, Dirikolu L, Mitchell MA. Characterization of long-term elution of platinum from carboplatin-impregnated calcium sulfate hemihydrate beads in vitro by two distinct sample collection methods.  Am J Vet Res. 2017 May;78(5):618-623. doi: 10.2460/ajvr.78.5.618. https://pubmed.ncbi.nlm.nih.gov/28441046/ 
 
Lundberg AP, Francis JM, Pajak M, Parkinson EI, Wycislo KL, Rosol TJ, Brown ME, London CA, Dirikolu L, Hergenrother PJ, Fan TM.  Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species.  Invest New Drugs. 2017 Apr;35(2):134-144.doi: 10.1007/s10637-016-0414-z.  https://pubmed.ncbi.nlm.nih.gov/27975234/ 
 
Rachel J. Tulipan RJ, Phillips H, Garrett LD, Dirikolu L, Mitchell MA. Elution of platinum from carboplatin-impregnated calcium sulfate hemihydrate beads in vitro.  Am J Vet Res. 2016 Nov;77(11):1252-1257. https://pubmed.ncbi.nlm.nih.gov/27805450/ 
 
Collins SP, Labelle AL, Dirikolu L, Li Z, Mitchell MA, Hamor RE.  Tear film concentrations of doxycycline following oral administration in ophthalmologically normal dogs.  J Am Vet Med Assoc. 2016 Sep 1;249(5):508-514. https://pubmed.ncbi.nlm.nih.gov/27556265/ 
 
Pieper J, Dirikolu L, Campbell K, Li Z, Mitchell M.  "Evaluation of the Effect of Fluconazole on the Pharmacokinetics of Cyclosporin A in Healthy Dogs after a Single Dose and at Steady State". J Vet Pharmacol Ther. 2016 Sep 1. doi: 10.1111/jvp.12352. https://pubmed.ncbi.nlm.nih.gov/27586063/

PUBMED PUBLICATIONS

Grants

Race horses testing (PI), Louisiana State Racing Commission, $1,442,233.00

Race horses testing (PI), Louisiana Racing Commission, $1,398,054.00

Race horses testing (PI), Louisiana Racing Commission, $1,355,269.00

Race horses testing (PI), Louisiana Racing Commission, $4,106,336.00

Hergenrother P (PI), Minutolo F, Seth P (Co-PI), Dirikolu L, Grant A (C-I) Design, synthesis, and evaluation of lactate dehydrogenase inhibitors, NIH (R01), $1,380,000.00