Shisheng Li

Shisheng Li


Department of Comparative Biomedical Sciences

LSU School of Veterinary Medicine
Louisiana State University
Baton Rouge, LA 70803



In the News



PhD, University of Wales, Swansea, 1997

MSc, Nankai University, 1988

BS, Henan Normal University, 1985

Research Interest

Mechanisms of DNA damage repair and mutagenesis

Teaching Interest

Cell and Molecular Biology

Awards & Honors

2019 Dean's Teacher Merit Honor Roll

2018 Dean's Teacher Merit Honor Roll

2017 Dean's Teacher Merit Honor Roll

2015 Faculty Distinguished Scholar Award

2009 Pfizer Award for Research Excellence


Gong, W., Holmberg, H., Huang, M. and Li. S. (2024) Interplay of the Tfb1 Pleckstrin homology domain with Rad2 and Rad4 in transcription coupled and global genomic nucleotide excision repair. Nucleic Acids Res. 2024, 1–14.

Sarsam, R. D., Xu, J., Lahiri, I., Gong, W., Oh, J., Zhou, Z., Chong, J., Hao, N., Li, S., Wang, D. and Leschziner, A. E. (2024) Elf1 promotes Rad26’s interaction with lesionarrested Pol II for transcription-coupled repair. PNAS 121, e2314245121.

Gong, W. and Li, S. (2023) Rpb7 Represses Transcription Coupled Nucleotide Excision Repair. J. Biol. Chem. 299, 104969.

Geijer, M. E., Zhou, D., Selvam, K., Steurer, B., Mukherjee, C., Evers, B., Cugusi, S., van Toorn, M., van der Woude, M., Janssens, R., Kok, Y. P., Gong, W., Raams, A., Lo, C., Lebbink, J. H. G.; Geverts, B.; Plummer, D. A.; Bezstarosti, K.; Theil, A. F.; Mitter, R.; Houtsmuller, A. B., Vermeulen, W., Demmers, J. A. A., Li, S., van Vugt, M. A. T. M., Lans, H., Bernards, R., Svejstrup, J. Q., Chaudhuri, A. R., Wyrick, J. J., Marteijn, J. A. (2021) Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability. Nat. Cell Biol 23, 608–619.

Selvam, K., Rahman, S.A., Forrester, D., Bao, A., Lieu, M. and Li, S. (2020) Histone H4 LRS mutations can attenuate UV mutagenesis without affecting PCNA ubiquitination or sumoylation. DNA Repair 95, 102959.

Ko, T. Sharma, R. and Li, S. (2020) Genome-wide screening identifies novel genes implicated in cellular sensitivity to BRAFV600E expression. Oncogene 39, 723-738.

Ko, T. and Li, S (2019) Genome-wide screening identifies novel genes and biological processes implicated in cisplatin resistance. FASEB J. 33, 7143-7154.

Selvam, K., Rahman, S. A. and Li, S. (2019) Histone H4 H75E mutation attenuates global genomic and Rad26-independent transcription-coupled nucleotide excision repair. Nucleic Acids Res. 47, 7392-7401.

Selvam, K., Ding, B., Sharma, R. and Li, S. (2019) Evidence that moderate eviction of Spt5 and promotion of error-free transcriptional bypass by Rad26 facilitates transcription coupled repair. J. Mol. Biol. 431, 1322-1338.

Li, W. and Li, S. (2017) Facilitators and repressors of transcription coupled DNA repair in Saccharomyces cerevisiae. Photochem. Photobiol. 93, 259-267.

Li, W., Selvam, K., Rahman, S. A. and Li, S. (2016) Sen1, the yeast homolog of human senataxin, plays a more direct role than Rad26 in transcription coupled DNA repair. Nucleic Acids Res. 44, 6794-6802.

Li, S. (2015). Transcription coupled nucleotide excision repair in the yeast Saccharomyces cerevisiae: the ambiguous role of Rad26. DNA Repair 36, 43-48.

Li, M., Ko, T. and Li, S. (2015). High-resolution digital mapping of N-methylpurines in human cells reveals modulation of their induction and repair by nearest-neighbor nucleotides. J. Biol. Chem. 290, 23148–23161. 


NSF, MCB-2102072, Li, Shisheng (PI), Regulation of transcription coupled DNA repair, 07/01/2021-06/30/2024

NIH/NIEHS (1R03ES033789), Li, Shisheng (PI), Implication of histone H4 LRS mutations in translesion synthesis and UV mutagenesis, 12/1/2021-11/30/2023  

NSF, MCB-1615550, Li, Shisheng (PI), The role of Sen1 in transcription coupled DNA repair (TCR), 

NSF, MCB-1244019, Li, Shisheng (PI), Dot1 and histone H3 K79 methylation in nucleotide excision repair, 
02/01/2013 – 01/31/2017